The Center for Central Luzon Studies was created under the Office of the Vice President for Academic Affairs with a mandate to support instruction through research and other academic related activities. It is a manifestation of the role CLSU plays as a regional university which fosters better understanding of the society it operates. Through research and instruction, the Center contributes to the attainment of national goals of nationhood and development. It primarily engages in research on Central Luzon history, society and culture; developing data bank that embodies information obtained from research; managing and enriching the University Museum that houses the artifacts gathered through research; linkages with external agencies; disseminating studies that are conducted to cultural groups as bases for the performing arts and to students and scientists for appropriate technology packaging; it also serves as the Regional Health Research Network of the Philippine Health Research Network, Inc., research arm of the Department of Health (DOH); and it is the center of the Central Luzon Culture and Arts Network (CL-CLAN). CCLS is affiliated with the Department of Tourism (DOT); National Commission on Culture and the Arts (NCCA); Philippine Social Sciences Council, Inc. (PSSC); ADHIKA ng Pilipinas, Inc.; Central Luzon Association of Museum (CLAM); Philippine Association of Museum (PAMI); and with the Provincial and Municipal Governments of Nueva Ecija.
The Center's most important functional unit is the Central Luzon Agricultural Museum, the only existing museum of its kind among State Colleges and Universities, and perhaps to date, entire the country. The CCLS was organized in 1986 in pursuit of the following objectives: (1) establish information and data bank of culture to reinforce and enrich the instruction program of the University; (2) serves as springboard for research on the generation of appropriate technologies for rural communities; and (3) help restore the Filipino pride in the ingenuity of this creation to further solidify the foundation of national identity.